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Studies using rat pinealocytes demonstrated that Epithalon upregulates both arylalkylamine N-acetyltransferase (AANAT) and phosphorylated CREB (pCREB), the rate-limiting enzymes in melatonin synthesis

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Paracellular intestinal permeability can be assessed in vivo by using different molecules (e.g., sugars, polyethylene glycols, 51 Cr-EDTA) and ex vivo in Ussing chambers combining electrophysiology and probes of different molecular sizes