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Table of contents The clinical trial data on GLP-1 medications and sleep The mechanism: how semaglutide affects sleep architecture Direct effects vs secondary effects: which one you have The three sleep disruption patterns we see most often What most articles get wrong about GLP-1 insomnia The structured sleep restoration protocol When sleep disruption means something more serious The dose-timing question: morning vs evening injection Medications that interact with semaglutide to worsen sleep When to stay the course vs when to adjust treatment FAQ Footer disclaimers The clinical trial data on GLP-1 medications and sleep The published STEP trials for semaglutide (Wegovy's active ingredient) provide the cleanest data on sleep-related adverse events: Check your GLP-1 eligibility Use our free BMI Calculator to see if you may qualify for provider-reviewed GLP-1 therapy