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Investigation of NNMT enzyme activity and inhibition Study of nicotinamide and methyl-donor metabolism Research into cellular methylation pathways Investigation of NAD+ metabolism Study of mitochondrial signaling and cellular energy pathways Research involving lipid-metabolism models Analysis of cellular metabolites and biochemical markers Investigation of gene and protein expression associated with NNMT pathways Comparative small-molecule and metabolic pathway research Key Research Areas NNMT enzyme biology Nicotinamide metabolism Methyl-donor metabolism Cellular methylation pathways NAD+ metabolism Mitochondrial signaling Cellular energy regulation Lipid-metabolism research Metabolic signaling pathways Molecular and biochemical research Scientific Background NNMT is an enzyme involved in the metabolism of nicotinamide and methyl-donor substrates and has been investigated in relation to cellular metabolic processes