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Furthermore, the drug significantly increased the mRNA and protein expression of PGC-1α and Sirt3 in aortic tissue, while decreasing the mRNA and protein expression of Epac1, Caspase-3, and Caspase-9
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Similarly, two members of the anthracycline antibiotic family, doxorubicin and daunorubicin hydrochloride decreased H 2 S production in HepG2 cells (Figure 3B, upper panels) although they induced cell toxicity at higher concentrations (Figure 3B, lower panels)
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