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Corin’s group introduced gamcemetinib (20) , which acts as an irreversible MK2 inhibitor through displacement of its chloride on the electron-deficient pyrimidyl ring with Cys140 thiolate, resulting in a stable thioether adduct that significantly inhibits heat-shock protein HSP27 phosphorylation

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Further studies are needed to find what benefits combining fisetin with NAD+ precursors confers